Learning, Performance, Neurorehabilitation
  • How do we learn and how does learning shape neural systems?
  • How does the brain learn to produce proper judgments and decisions?
  • What cognitive and neural factors influence the improvement or deterioration of our performance?
  • How do our perceptual systems develop through experience, and how do they reorganize following damage to the nervous system?
  • Apply this knowledge to guide learning and neurorehabilitation.
Learning rests on the experience of reward and punishment.
Rewards and penalties appear to have profoundly distinct effects on behavior.
Effects of a gain or a loss on subsequent choice.
An intent of a paralyzed person can be read out from the brain to provide a communication channel.
Electrodes implanted onto the human brain provide a new opportunity to interface the nervous system of paralyzed or locked-in patients.
Example of an X-ray image of an electrode grid implanted into a patient with intractable epilepsy.
A person's intent to make a movement can be read out from the activity of the brain.
A two-dimensional hand movement (gray) predicted (green) from neural activity recorded using implanted electrodes.
Cortical regions involved in a subject's intent to move the thumb. Left: cortical potentials. Right: gamma activity.
Speech-related information can be extracted from neural activity of auditory cortex.
Core auditory regions track the envelope of speech.
A person's upcoming decision can be predicted from cortical activity.
Neural activity recorded with EEG while subjects decided to make a button press or a saccade.
Ultrasonic neural modulation.
Ultrasound has been shown to modulate neuronal activity.
We are investigating the mechanisms of the ultrasonic effect on biological tissue.
Impact of brain lesions on behavior.
Patients with lesions in parietal cortex often suffer from hemi-spatial neglect, a deficit of spatial processing.
We are investigating the basis of this deficit by inducing reversible lesions in specific regions of monkey parietal cortex.
Muscimol-mediated reversible lesions scanned with MRI.